Description
The Parker PROPOR BR bioburden reduction filter PROPOR BR
PROPOR BR filters are for fast and cost-effective reduction of bioburden from fluids and solutions in the pharmaceutical industry. PROPOR BR filters include in their body an integrated pre-filtration layer to pre-filtrate liquids before they reach the finest part of the filter. The pre-filtration layer reduces dirt and large particles, protecting the polyethersulfone (PES) membrane, extending its durability and lifetime. (PFAS-free models available)
Bioburden reduction filter technical information
Filtration value: 0.2 microns. Length: 2.5 to 40 inches (65 to 1000 mm). Seal material: Silicone, EPDM, Viton. Filter Structure: Pleated. Grade: MURUS and DEMICAP capsules are available non-sterile or gamma irradiated. MURUS capsule configuration: In-line and T-Port.
Compliance with specifications:
- FDA 21 CFR part 177 compliant.
- USP Class VI plastics – 121°C.
Materials of manufacture:
- Filtration membrane: Polyethersulfone
- Membrane pre-filter: Polyester
- Upward support: Polyester
- Descending support: Polyester
Filter cartridges
- Inner support core: Polypropylene
- Outer protective cage: Polypropylene
- Plugs: Nylon
- Plug insert: 316L stainless steel
Syringe filters
- Body: Polypropylene
MURUS capsules
- Core: Polypropylene
- Cover: Polypropylene
- Plug insert: 316L Stainless Steel
- Capsule body: Polypropylene
- Capsule vent seals: Silicone
DEMICAP capsules
- Core: Polypropylene
- Cover: Polypropylene
- Plugs: Nylon
- Capsule body: Nylon
- Capsule vent seals: Silicone
- Filling bell: Polycarbonate
Operating temperature
Filter cartridges Maximum continuous operating temperature 70°C (158°F) Short-term higher temperatures during CIP:
- Up to 20°C (68°F) @ 5.0 barg (72.5 psig)
- Up to 40°C (104°F) @ 4.0 barg (58.0 psig)
- Up to 60°C (140°F) @ 3.0 barg (43.5 psig)
- Up to 80°C (176°F) @ 2.0 barg (29.0 psig)
- Up to 90°C (194°F) @ 1.7 barg (24.6 psig)
MURUS capsules
- Up to 25°C (77°F) @ 5.5 barg (79.7 psig)
- Up to 60°C (140°F) @ 2.8 barg (40.6 psig)
DEMICAP capsules
- Up to 40°C (104°F) at line pressures up to 5.0 barg (72.0 psig)
End cap configuration
Filter cartridges
- BF / 226 Bayonet
- End / 222
- Flat Top / 222
- Recess / 222
- BF / 222 Bayonet
Demi cartridge
- TRUSEAL
- 116
- Demi Stub
- Demi A B Std
Input connection size
MURUS capsules
- ¾” Tri-Clamp Clamp
- 1½” Tri-Clamp Clamp
- 1″ hose nozzle
- 1″ Tri-Clamp Clamp
- ½” hose nozzle
DEMICAP capsules
- 1″ Tri-Clamp Clamp
- ½” male NPT
- ½” hose nozzle
- Stepped hose nozzle
- ¼” male NPT
- Walther QC
- Grommel / QC
Output connection size
MURUS capsules
- ¾” Tri-Clamp Clamp
- 1½” Tri-Clamp Clamp
- 1″ hose nozzle
- 1″ Tri-Clamp Clamp
- ½” hose nozzle
DEMICAP capsules
- 1″ Tri-Clamp Clamp
- ½” male NPT
- ½” hose nozzle
- Stepped hose nozzle
- ¼” male NPT
- Walther QC
- Grommel / QC
Retention of LRV > 5 by Brevundimonas diminuta
The filter can reduce the concentration of minute Brevundimonas by a factor of more than 100,000 times. (LVR > 5) So the bioburden reduction is highly efficient.
Built-in pre-filtration to prevent clogging
The addition of a pre-filtering layer helps extend the life of the polyethersulfone cartridge by retaining large particles that could cause clogging.
Low adherence. Low product loss
Designed to have low adherence and avoid retaining molecules from the filtered liquid. This minimizes product loss in the microbial reduction process.
PROPOR BR filter applications
The polyethersulfone membrane allows a bioburden reduction greater than 5 (in logarithmic terms). This high microbial protection and bioburden reduction capability of PROPOR BR is suitable for applications of large volume liquid preparations that are administered intravenously (Large Volume Parenterals / LVP) in their bioburden reduction stage, before the fluid reaches the terminal sterilization filters.
